The Integrated Phenotype

The integrated phenotype.

Proper functioning of complex phenotypes requires that multiple traits work together. Examination of relationships among traits within and between complex characters and how they interact to function as a whole organism is critical to advancing our understanding of evolutionary developmental plasticity. Phenotypic integration refers to the relationships among multiple characters of a complex ph...

Toward an integrated concept of the phenotype

A major problem that transcends the boundaries of biological disciplines is reconciliation of phenotypic change and stability. On the one hand, individual organisms are extraordinarily plastic, responding to life-stage transitions, seasonal cues and environmental change. Some of these changes are permanent and some are reversible, occurring thousands of times during a single lifetime. On the ot...

Toward fully integrated mouse phenotype data

The multitude of murine genetic resources available worldwide, including inbred mouse lines, spontaneous and induced mutants, and ES lines ready for conditional gene targeting, represent a unique resource for the biomedical community. Recent international efforts are striving to complete the functional annotation the mouse genome, which will allow a systems-based view of mammalian biological ne...

Inference on biological mechanisms using an integrated phenotype prediction model.

We propose a methodology for constructing an integrated phenotype prediction model that accounts for multiple pathways regulating a targeted phenotype. The method uses multiple prediction models, each expressing a particular pattern of gene-to-gene interrelationship, such as epistasis. We also propose a methodology using Gene Ontology annotations to infer a biological mechanism from the integra...

Chromosome Duplication (14q) and The Genotype Phenotype Correlation